HLA and HIV

Cell Antigen versus Virus

© Judy Arbique

Aug 7, 2007

There are a number of disease processes that are related to human leukocyte antigen (HLA) types.


A human leukocyte antigen (HLA) typing of HLA-B57 has been associated with slower progression from infection with human immunodeficiency virus (HIV) to terminal auto-immune deficiency syndrome (AIDS).

Human leukocyte antigens (HLA) are proteins that are expressed on the surface of a number of different human cell types. Individuals who carry antigens for HLA-B57 have been associated with slower progression from initial HIV infection to terminal auto-immune deficiency syndrome )AIDS).

HLA -B57 carrying individuals maintain plasma HIV virus levels below 50 copies/ml, and normal CD4 counts (type of white blood cell) without treatment.

The HLA-B57 antigen has not been found to protect against contracting HIV infection, but HIV infected individuals with HLA-57 antigens present less frequently with symptoms of acute infection .


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